Malaria

Clip domain Ser proteases function in the malaria vector Anopheles gambiae

Published in Gene Therapy Weekly, January 26th, 2006

A study from Australia has documented that the two clip domain Ser proteases have multiple functions in the malaria vector Anopheles gambiae.

"The malaria vector A. gambiae is capable of multiple immune responses against Plasmodium ookinetes. Accumulating evidence in several species suggests the involvement of Ser protease cascades in the initiation and coordination of immune responses."

"We report molecular and reverse genetic characterization of two mosquito clip domain Ser proteases, CLIPB14 and CLIPB15, which share structural similarity to proteases involved in prophenoloxidase activation in other insects," wrote J. Volz and...

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Source: Gene Therapy Weekly (2006-01-26)

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