Infectious Diseases

Induced expression of melittin suppresses Chlamydia and Mycoplasma infections

Published in Gene Therapy Weekly, January 26th, 2006

Research from Russia has reported on the effect of induced expression of an antimicrobial peptide melittin on Chlamydia trachomatis and Mycoplasma hominis infections in vivo.

"A plasmid construct was designed in which the gene of antimicrobial peptide melittin is controlled by the tetracycline-responsive promoter of human cytomegalovirus, aided by a constitutively expressed trans-activator protein gene," wrote V.N. Lazarev and colleagues, Ministry of Health & Social Development of the Russian Federation.

"Its vaginal administration and induction of melittin gene transcription with doxycycline markedly suppressed subsequent genital tract...

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Source: Gene Therapy Weekly (2006-01-26)

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