Vaccine Development

Turning off molecular "brake" boosts immune response in mouse model of HIV

Published in Gene Therapy Weekly, January 26th, 2006

Researchers at Baylor College of Medicine (BCM) in Houston have reason to believe their unorthodox vaccine could one day help to prevent or control HIV infection.

In the study, published in the January 2, 2006, edition of Public Library of Science Medicine, the immune response in mice was boosted by removing the host's natural immune "brake." By unleashing the immune system's full potential in conjunction with conventional antiretroviral treatment, HIV could be treated more effectively or prevented altogether.

"A lot of vaccines work very well in dealing with some pathogens, but for HIV, the natural immune response usually fails," said Si-Yi...

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Source: Gene Therapy Weekly (2006-01-26)

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