Tobacco Use
Nrf2 is activated by aqueous extracts of cigarette smoke
Published in Gene Therapy Weekly, February 2nd, 2006
"CS is a complex chemical mixture estimated to be composed of up to 5000 different chemicals, many of which are prooxidant. Here we show that, at least in vitro, the cellular response designed to combat oxidative stress resulting from CS exposure is primarily controlled by the transcription factor Nrf2, a principal inducer of antioxidant and phase II-related genes," wrote C. Knorr-Wittmann and colleagues, Philip Morris Research Laboratories GmbH.
"The prominent role of Nrf2...
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Source: Gene Therapy Weekly (2006-02-02)
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