Gene Therapy Weekly

Antisense Technology - Antisense knockdown of cyclin E does not affect the midblastula transition

Gene Therapy - Adenovirus genome insertion sites utilize splicing machinery for therapeutic gene expression

Gene Therapy - Erythropoietin gene transfer reduces risk of germ cell loss caused by cryptorchidism

Gene Therapy - Norepinephrine transporter contributes to PET of gene therapy

Gene Therapy - Sea urchin sns chromatin insulator characterized in erythroid cells

Acute Respiratory Distress Syndrome - Study reveals new player in sepsis-associated condition

Adenovirus Vector - Viral vector mitigates neutralization by antiviral antibodies

Alzheimer Disease - New findings in Alzheimer disease described

Angiology - New research in the area of angiology detailed

Antiviral Therapy - Gemcitabine enhances ganciclovir-mediated bystander cytotoxicity

Apoptosis - Apolipoprotein A-IV attenuates oxidant-induced apoptosis

Apoptosis - HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis

Apoptosis - Heat shock protein protects hippocampal progenitor cells from apoptosis

Apoptosis - JNK activation contributes to DP5 induction and apoptosis after spinal cord injury

Arthritis - Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis

Biomedical Engineering - A new molecular conjugate vector improves tumor targeting, imaging, and therapy

Bladder Cancer - Abating heat shock protein 70 caused enhanced sensitivity to mitomycin C in bladder cancer

Bone Development - Recombinant bone morphogenetic protein is safe for spinal fusion use

Bone Marrow - Recombinant bone morphogenetic protein is a safe bone-stimulating agent

Breast Cancer - Matrix metalloproteinase-1 implicated in breast tumor growth

Breast Cancer - Molecular interaction found to trigger particularly aggressive form of disease

Breast Cancer - PrxII expression related to radiation-resistant MCF-7 breast cancer cells

Cancer Gene Therapy - Adenoviral vectors targeting angiogenesis enhance prostate tumor suppression

Cancer Gene Therapy - Antisense Bcl-2 sensitizes prostate cancer cells to radiation

Cancer Gene Therapy - Combination nonviral gene therapy and radiotherapy is effective for squamous cell carcinoma

Cancer Gene Therapy - Endothelial cell transplantation permits gene therapy in experimental gliomas

Cancer Gene Therapy - Nonviral jet-injection gene transfer is an effective therapy for colon carcinoma

Cancer Gene Therapy - Retargeted gene therapy blankets malignant glioma without triggering angiogenesis

Cancer Therapy - Constitutively active Notch-1 increases synthesis of the PTEN tumor suppressor

Cancer Therapy - Smad7 expression may repress metastasis of mouse mammary carcinoma cells

Cardiology - Calreticulin regulates myocardiac cell sensitivity to oxidative stress

Cervical Cancer - Researchers publish new studies and findings in the area of cervical cancer

Clinical Trials - Favorable interim phase 2b results for PAD treatment reported

Clinical Trials - Multidose study of drug to reduce double-stranded DNA in lupus patients to be initiated

Collaborations - Five-year collaboration with Duke set to analyze genomic information from patient samples

Cystic Fibrosis Therapy - Model for cystic fibrosis gene therapy has been developed

DNA Research - Engineered human dicentric chromosomes show centromere plasticity

DNA Research - Impaired DNA replication within progenitor cell pools promotes leukemogenesis

DNA Research - Novel INHAT repressor modulates the transcriptional activity of p53

DNA Research - Nrf2 carboxy-terminal Neh3 domain is required for transcriptional activation

DNA Research - Skeletal muscle gene expression is enhanced by a polymer excipient Pluronic P85

Developmental Biology - Lhx2 mediates the activity of Six3 in zebrafish forebrain growth

Developmental Biology - Mice deficient in Ext2 lack heparan sulfate and develop exostoses

Developmental Biology - Retinoblastoma and RNA interference-related genes negatively regulate nuclear divisions

Developmental Biology - The zebrafish dorsal axis is apparent at the four-cell stage

Diabetes Therapy - Hepatic insulin gene therapy prevents deterioration of vascular function

Diabetes Therapy - Researchers' data advance diabetes therapy research

Drug Development - European Medicines Agency grants orphan drug status to CF treatment denufosol tetrasodium

Ebola Virus - Gene-specific therapies protect non-human primates from lethal disease

Endocytosis - Endosomal transport of ErbB-2 functions in nuclear entry of cell surface receptor

Enzymology - Catalase plays a critical role in the survival of human macrophages

Finance - Biotech company reports 22% increase in fourth-quarter revenue