Antisense Technology
Antisense knockdown of cyclin E does not affect the midblastula transition
Published in Gene Therapy Weekly, February 9th, 2006
"In X. laevis embryos, cyclin E protein remains constitutively high throughout the first 12 cell cycles following fertilization until the onset of the MBT (after the 12th cell cycle) when it undergoes a dramatic reduction."
M.K. Slevin and colleagues, University of New Mexico, wrote, "The disappearance of cyclin E at the MBT occurs independently of active cell cycle progression, zygotic transcription, protein synthesis and the nuclear to cytoplasmic ratio. This has suggested that cyclin...
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Source: Gene Therapy Weekly (2006-02-09)
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