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Gene Therapy

Norepinephrine transporter contributes to PET of gene therapy

Published in Gene Therapy Weekly, February 9th, 2006

A study from the Netherlands has documented the human norepinephrine transporter (hNET) in combination with C-11-m-hydroxyephedrine (mHED) as a reporter gene/reporter probe for positron emission tomography (PET) of gene therapy.

"Although the herpes simplex virus Thy kinase gene has been frequently applied as a reporter gene for monitoring gene transfection in animals, it has some intrinsic limitations for use in humans. In our search for a reporter gene that lacks these limitations, we have evaluated the feasibility of the hNET as a reporter gene in combination with the reporter probe mHED for PET."

"An adenoviral vector (AdTrack-hNET) containing...

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