Published in Gene Therapy Weekly, February 9th, 2006
"Hepatocyte nuclear factor 1 beta (HNF1 beta, TCF2) is a tissue-specific transcription factor whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy and maturity onset diabetes of the young (MODY5). Furthermore, HNF1 beta overexpression has been observed in clear cell cancer of the ovary," wrote S. Senkel and colleagues, Universitatsklinikum Essen.
"To identify potential HNF1 beta target genes whose activity may be deregulated in human patients, we...
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