Cancer Gene Therapy

Transfected, microencapsulated cells and ifosfamide treat peritoneal cancer

Published in Gene Therapy Weekly, February 16th, 2006

According to recent research from Germany, CYP2B1 transfected, microencapsulated cells and ifosfamide treat peritoneal cancer.

"The prognosis of peritoneal spread from gastrointestinal cancer and subsequent malignant ascites is poor, and current medical treatments available are mostly ineffective. Targeted chemotherapy with intraperitoneal prodrug activation may be a beneficial new approach," wrote S. Samel and colleagues, University of Gottingen.

"L293 cells were genetically modified to express the cytochrome P450 enzyme 2B1 under the control of a cytomegalovirus immediate early promoter. This CYP2B1 enzyme converts ifosfamide to its active...

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Source: Gene Therapy Weekly (2006-02-16)

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