Gene Therapy

Leptin receptor installation improves energy balance and reproductive status of obese females

Published in Gene Therapy Weekly, February 16th, 2006

According to research from the United States, recombinant adeno-associated virus (rAAV)-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats.

"Leptin is a hormone secreted primarily by white adipocytes that regulates energy homeostasis and reproduction via CNS receptors. Koletsky (f/f) rats with a leptin receptor (OB-Rb) gene mutation are obese, diabetic and infertile."

"We employed rAAV vectors to transfer the human OB-Rb gene into the brains of female Koletsky rats to identify sites of leptin action in the brain. rAAV-OB-Rb was microinjected into the medial preoptic area (MPOA), the...

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Source: Gene Therapy Weekly (2006-02-16)

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