Huntington Disease

Dysregulation mediates aberrant caspase-1 activation in Huntington disease

Published in Gene Therapy Weekly, February 16th, 2006

According to recent research from the United States, dysregulation of receptor interacting protein-2 and caspase recruitment domain (CARD) only protein (Cop) mediates aberrant caspase-1 activation in Huntington disease (HD).

"Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of HD. However, mechanisms regulating the activation of this apical caspase in cell death are not known," wrote X. Wang and colleagues, Harvard University.

"Receptor interacting protein-2 (Rip2) and Cop are two CARD proteins with significant homology to the caspase-1 CARD and modulate caspase-1...

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Source: Gene Therapy Weekly (2006-02-16)

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