Gene Therapy

Transduction of dendritic cells is enhanced by adeno-associated virus

Published in Gene Therapy Weekly, February 16th, 2006

Research from the United States has reported that transduction of mouse bone marrow-derived dendritic cells (DC) is enhanced by repetitive infection with self-complementary adeno-associated virus (AAV) 6 combined with immunostimulatory ligands.

"The potential of AAV-based vectors in human gene therapy is being explored for several diseases. Although sustained transgene expression and low vector-associated cellular immunity are attractive features of recombinant (r) AAV, the wider application of rAAV vectors encapsidated in serotype 2 capsid is hampered by poor transduction efficiency in many target tissues."

"These include ex vivo-generated DC, which...

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Source: Gene Therapy Weekly (2006-02-16)

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