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Angiology

Phosphatidylinositide 3-kinase supports late-stage fibroblast growth factor-1-mediated angiogenesis

Published in Gene Therapy Weekly, February 16th, 2006

Phosphatidylinositide 3-kinase (PI3K) supports late-stage fibroblast growth factor-1 (FGF-1)-mediated angiogenesis.

According to researchers in the United States, "we previously reported that overexpression of a secreted version of fibroblast growth factor-1 (sp-FGF-1) has the ability to induce angiogenesis in the chicken chorioallantoic membrane (CAM). In our current study, we examine the effects of sp-FGF-1 through a time course analysis of angiogenesis in the chicken CAM on days 3, 4, and 5 after gene transfection."

"Significant angiogenesis was observed on days 4 and 5 after gene transfection in the CAM assay. To evaluate the role of PI3K...

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