Mutations
Methylthioadenosine phosphorylase mutations detected in human biliary tract cancers
Published in Gene Therapy Weekly, February 23rd, 2006
"The p16(INK4A)/CDKN2A gene on chromosome 9p21 is a site of frequent allelic loss in human cancers, and in a subset of cases, homozygous deletions at this locus encompass the telomeric methylthioadenosine phosphorylase (MTAP) gene."
"The MTAP gene product is the principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms," wrote C.A. Karikari and colleagues, Johns Hopkins University.
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Source: Gene Therapy Weekly (2006-02-23)
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