Parkinson Disease
Pathogenesis of alpha-synuclein cellular toxicity in Parkinson Disease indicated
Published in Gene Therapy Weekly, February 23rd, 2006
"Parkinson disease (PD) is a neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. Alpha-synuclein is a major component of Lewy bodies in sporadic PD, and mutations in alpha-synuclein cause autosomal-dominant hereditary PD."
"Here," wrote W.W. Smith and colleagues, Johns Hopkins University, "we generated A53T mutant alpha-synuclein-inducible PC12 cell lines using the Tet-off regulatory system."
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Source: Gene Therapy Weekly (2006-02-23)
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