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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . March 2nd, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cancer Genetics - PKCalpha expression is regulated by Elk-1 and MZF-1 in hepatocellular carcinoma

Gene Therapy - BACE1 deletion rescues temporal memory deficits in Alzheimer mouse models

Gene Therapy - Direct targeting of modified tumor cells to Fc gamma RI triggers cytotoxicity

Gene Therapy - Inhibitor of Apoptosis Protein 2 regulates innate immune signaling in Drosophila

Gene Therapy - STAT3 activation is differentially regulated in squamous cell carcinomas

Addiction Medicine - New findings in addiction medicine described

Alzheimer Disease - Genomic regulation in microglia perturbs genes relevant to Alzheimer disease

Anti-Inflammatories - COX mechanisms play a role in maintaining pain hypersensitivity

Apoptosis - Arsenic trioxide is a novel human neutrophil pro-apoptotic agent

Apoptosis - Data advance knowledge in apoptosis research

Apoptosis - Phorbol ester-induced apoptosis in prostate cancer cells involves protein kinase C delta

Apoptosis - Suppression of PKCalpha may contribute to hepatic apoptosis during sepsis

Apoptosis - p53 deficiency rescues apoptosis and differentiation of multiple cell types

Atherosclerosis - Local vascular endothelial growth factor gene transfer may not prevent arterial restenosis

Biomedical Engineering - Injectable nanofibers allow controlled protein delivery to myocardium

Bone Development - Bone morphogenetic protein-15 helps regulate oocyte maturation

Bone Development - The peripheral cannabinoid receptor CB2 regulates bone mass

Brain Cancer - Molecularly targeted therapy for pediatric brain tumors discussed

Breast Cancer - PIK3Ca mutations correlate with gene expression and drug sensitivity

Cancer Gene Therapy -  Spirulina platensis phycocyanin antitumoral activities are affected by CD59

Cancer Gene Therapy - AIM2 suppresses human breast cancer cell proliferation and mammary tumor growth

Cancer Gene Therapy - Adenovirus vector is more infective for esophageal and oral carcinoma cells

Cancer Gene Therapy - p27(KIP1) prolongs cell cycle and induces apoptosis in gastric cancer cells

Cancer Gene Therapy - p53 cDNA sequence mutations are introduced by a retroviral vector

Cancer Research - Genetics research may hold key to destroying cancer cells

Cancer Research - Protein suppresses growth of head and neck tumors

Cancer Therapy - Alemtuzumab induces caspase-independent cell death in lymphocytic leukemia cells

Chemotherapy - Findings describe new data in chemotherapy research

Clinical Trials - Enrollment opened in phase 2 trial of DNA vaccine against cytomegalovirus

Cystic Fibrosis - Cationic lipid mediated gene transfer is inhibitory in CF tracheal gland cells

Cytokines - Splenocyte cytokines are induced by heat shock proteins and concanavalin A

DNA Research - Transcriptional activation is stimulated by bidirectional RNA polymerase II elongation

Depression - Gene therapy used to prevent depression in mice

Developmental Biology - Crescent modulates Wnt signaling in early Xenopus embryogenesis

Developmental Biology - Rac1 activation by RhoG regulates cell migration

Diet & Nutrition - Beef tallow increases linoleic acid potency in reduction of mammary tumor metastasis

Disease Associations - Natural killer cells are immunoselected that lack stress-inducible ULBP

Doxorubicin - Doxoform suspected as a prodrug for doxazolidine

Finance - TEDCO awards grant for a smallpox DNA vaccine delivery project

Gastric Cancer - Low intra-tumor variability revealed in gastric cancer

Gastric Cancer - Polo-like kinase 1 depletion inhibits mitosis and apoptosis of gastric cancer cells

Genetics & Genomics - RNAi Consortium member introduces lentiviral shRNA gene family set for gene silencing

Genetics & Genomics - SNAI1, functioning as E-cadherin repressor, is implicated in gastric cancer

Genetics & Genomics - Scientists force viruses to evolve as better delivery vehicles for gene therapy

Gynecology - Calcyclin-binding protein may help regulate apoptosis during early pregnancy

HIV/AIDS Genetics - HIV-1 RNA binding protein interacts with Dicer and functions in RNA silencing

HIV/AIDS Mutations - HIV-1 subdomain insertions alter polymerase fidelity and mutation frequencies

Head & Neck Cancer - p63 implicated as survival factor for tumor cells of head and neck cancers

Hepatitis Vaccines - HBV CpG-optimized protein and DNA vaccines perform poorly in chimpanzees

Imaging - Imaging reveals effects of bronchodilator and airway clearance treatment in cystic fibrosis

Infectious Diseases -  Haemophilus influenzae adherence upregulates ICAM-1 expression

Inflammatory Bowel Disease - Inflammatory bowel disease is treatable using NF-kappaB decoy oligonucleotides

Lung Cancer - Tumor cell-stromal fibroblast interaction revealed in model of human small-cell lung cancer

Natural Killer Cells - NK cell-mediated cytotoxicity involves three sequential membrane impairment steps

Neuroscience - Caspase-1 activates caspase-6 in human apoptotic neurons

Neuroscience - Recent findings illuminate research in neuroscience

Neuroscience - Research in neuroscience provides new insights

Ovarian Cancer - Research add new data to ovarian cancer body of knowledge

Ovarian Cancer - Suppression of natural killer cell response mediated by the ovarian tumor marker CA125

Patents - Transdermal science company serves patent infringement notice for insulin delivery system

Pharmaceutical Research - Drug delivery company, Donaldson launch jointly developed nanofiber cell culture product

Prodrugs - Tumor necrosis factor prodrug restores membrane TNF-like activity

Product Licensing - Hepatitis C virus license agreement signed with Chiron

Reproductive Biology - Recombinant human lutropin alfa is not useful in late stimulation assisted reproduction cycles

Rett Syndrome - Brain derived neurotrophic factor alleviates symptoms of Rett syndrome in mouse model

Rheumatoid Arthritis - Pristane induces MHC class II-restricted, arthritogenic T cells

Stem Cell Research - Functional mammary gland generated from a single stem cell

T Cells - CD8+ and CD4+ T-cell tolerances can be broken

T Cells - TNF receptor type 2 co-stimulates antigen-driven T cell responses in vivo

Thrombocytopenia - Recombinant factor VIIa can control bleeding caused by thrombocytopenia

Transplant Medicine - Studies describe new findings in transplant medicine research

Vector Development - Dendrimers in gene delivery are focus of review

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