Cystic Fibrosis
Cationic lipid mediated gene transfer is inhibitory in CF tracheal gland cells
Published in Gene Therapy Weekly, March 2nd, 2006
"In vivo, tracheal gland serous cells highly express the CF transmembrane conductance regulator (CFTR) gene. This gene is mutated in the lethal monogenic disease CF," wrote S. Bastonero and colleagues, INSERM U724.
"Clinical trials in which the human CFTR cDNA was delivered to the respiratory epithelia of CF patients have resulted in weak and transient gene expression."
The researchers explained, "As CF is characterized by mucus...
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Source: Gene Therapy Weekly (2006-03-02)
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