Developmental Biology
Rac1 activation by RhoG regulates cell migration
Published in Gene Therapy Weekly, March 2nd, 2006
"Cell migration is essential for normal development and many pathological processes. Rho-family small GTPases play important roles in this event."
"In particular," wrote H. Katoh and colleagues, Kyoto University, "Rac regulates lamellipodia formation at the leading edge during migration. The small GTPase RhoG activates Rac through its effector ELMO and the ELMO-binding protein Dock180, which functions as a Rac-specific guanine nucleotide exchange factor."
"Here we investigated the role of RhoG in cell migration. RNA...
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Source: Gene Therapy Weekly (2006-03-02)
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