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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . March 9th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Glioblastomas - Glioblastoma subgroups possess distinct transcription profiles

Sickle Cell Anemia - Sickle cell anemia treated by coregulating globin transgene expression and RNA interference

Vector Development - Adeno-associated virus transduction regulates AADC expression

Vector Development - Tat-related gene transporter designed and synthesized

Virology - Antiviral siRNAs completely cured persistent virus infections

Apoptosis - Recent studies add new data to apoptosis research

Apoptosis - Reports add new data to apoptosis research

Bladder Cancer - p53 protein transduction therapy targets and inhibits bladder cancer cell growth

Bone Development - Bone response to hydroxyapatite scaffolds is visualized

Breast Cancer - E2F-HDAC complexes negatively regulate breast cancer tumor suppressor gene

Breast Cancer - Researchers publish new studies and findings in the area of breast cancer

Breast Cancer - Stat3 signaling induces survivin gene expression and apoptosis resistance in breast cancer cells

Cancer Gene Therapy - Analogue 4 is a strong candidate for gene therapy of lung tumors

Cancer Gene Therapy - Antisense-cisplatin combination treatment is potentially useful in breast cancer

Cancer Gene Therapy - Co-transfection into lung cancer cells line can increase chemosensitivity

Cancer Gene Therapy - Combination gene therapy increases anti-tumor effect in a CT26 tumor model

Cancer Gene Therapy - Combination therapy produces adenovirus transduction and enhanced therapeutic efficacy

Cancer Gene Therapy - DNA methyltransferase inhibition prevents prostate cancer tumorigenesis

Cancer Gene Therapy - Pancreatic carcinoma can be treated by adenoviral mediated gene transfer of vasostatin

Cancer Gene Therapy - TRAIL recombinant adenovirus displays antitumor activity in human malignant glioma cells

Cancer Therapy - COX-2 inhibition augments the efficacy of a cancer vaccine

Cancer Therapy - Topoisomerase II inhibitors enhanced by using polypeptide inhibitor of c-Myc

Cirrhosis - rhHGF-activator stimulates cirrhotic liver regeneration

Colorectal Cancer - Mutations spread in the normal colon by crypt fission

Complementary & Alternative Medicine - Curcumin uses transcription factor Egr-1 to suppress epidermal growth factor receptor expression

Cystic Fibrosis - Culture of murine nasal epithelia models cystic fibrosis

Cytomegalovirus Pathogenesis - CMV-encoded G-protein-coupled receptors actively modulate cellular signaling networks

Developmental Biology - Calcitonin gene-related peptide expression clarified in the superior colliculus

Drug Development - New findings in drug development described

Endocrinology - Researchers publish new studies and findings in the area of endocrinology

Endocytosis - Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

Epstein-Barr Virus - Recent findings illuminate research in Epstein-Barr virus

Gene Delivery - Tumor specific gene delivery is achieved using a pH-responsive system

Gene Research - Antisense drug restores dystrophin in Duchenne muscular dystrophy in mouse model study

Gene Therapy - Reports advance knowledge in gene therapy research

Genetic Engineering - Intravenous MDMA self-administration in naive mice modeled reliably

Genetics & Genomics - Cellular immortalization is associated with concordant copy number and transcriptional activity

Genetics & Genomics - DNA-focused diagnostics company to supply Children's Hospital with genetic test reagents

Genetics & Genomics - MicroRNA gene expression quantified by a single-molecule method

Germ Cell Development - Germ cell expression patterns are related to meiosis and postmeiotic development

Gliomas - AKT pathway contributes to the development and progression of gliomas

Hematology - A vascular wall protein inhibits collagen-induced platelet aggregation

Hepatitis C Virus - HCV NS3 protein protects dendritic cells from recombinant virus expressing NS3

Hepatitis C Virus - HCV affects dendritic cell cytokine induction and T-cell stimulation

Hepatitis C Virus - HCV transmission from B-cells to hepatoma cells occurs by cell-to-cell contact

Hepatitis C Virus - Poly pyrimidine tract-binding protein is required for HCV RNA replication

Hepatitis C Virus - Viral fitness limits HCV variability within immunological epitopes

Hypertension - Researchers describe findings in hypertension studies

Ischemia - HSP70 functions in Ca2+ homeostasis in ischemic ventricular myocytes

Lung Cancer - Hepatoma-derived growth factor encourages tumor growth and invasion

Lymphocytes - RNA electroporation allows high-efficiency transfection of primary human and mouse T lymphocytes

Lymphoma - Ablation of oncogenic ALK used to treat anaplastic large-cell lymphomas

Market Analysis - Apoptosis becomes a new focus for pharmaceutical companies

Melanoma - Vav/Rho GTPase signaling activation controls dependent melanoma cell invasion

Metabolic Syndrome - DNA repair gene linked to metabolic syndrome

Multiple Myeloma Vaccine - Adenoviral-mediated gene transfer results in cytotoxicity of multiple myeloma cells

Multiple Sclerosis Therapy - Bone marrow transplant plus gene therapy ameliorates encephalomyelitis

Myeloid Tumors - Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors

Neuroscience - Cdk5 contributes to actin organization and cortical neuronal migration

Neuroscience - Researchers publish new studies and findings in the area of neuroscience

Oncology - Therapeutic targeting of RhoB may control tumor hypoxia and proliferation

Ovarian Cancer - HIF-2 alpha signal transduction in ovarian cancer cells might not involve Bcl-2A

Parkinson Disease - Recent findings in Parkinson disease provide new insights

Product Licensing - Licensing and asset agreement signed to distribute antibodies to druggable gene targets

Prostate Cancer - Oligonucleotide microarrays allow assessment of prostate cancer treatment

Prostate Cancer - Reports advance knowledge in prostate cancer research

Prostate Cancer Vaccines - New findings in the area of prostate cancer vaccines described

Proteomics - Endostatin inhibits angiogenesis in a species-specific fashion

Proteomics - Human protein phosphatase 2A catalytic subunits can be produced by baculovirus

Proteomics - Hypoxia inducible factor is a platelet derived growth factor regulator in cancer cells

Sickle Cell Disease - Protein reduces inflammation, inhibits vaso-occlusion in mice with sickle cell disease

Stem Cell Research - CTL response is not elicited by allogeneic MUC class I molecules

Systemic Lupus Erythematosus - Toll-like receptor 9 signaling protects against murine lupus

Vaccines Vector - Researchers' work adds to vaccines vector body of knowledge

Vector Development - Binary AdEasy vector systems use Tet-regulated transgene expression

Vector Development - Findings describe new data in vector development research

Vector Development - High expression levels of alpha 1-antitrypsin are mediated by adeno-associated virus

Vector Development - New findings in the area of vector development described

Vector Development - New findings in vector development described

Viral Encephalitis - RNA interference used to treat viral encephalitis

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