Published in Gene Therapy Weekly, March 16th, 2006
"Genetic alterations that lead to loss or changes in tumor-suppressor genes are known to contribute to oral carcinogenesis. Traditional molecular methods to detect such losses have relied on mutation analysis or deletion of the gene," scientists writing in the journal Lancet Oncology reported.
"However, epigenetic mechanisms could also contribute to silencing of tumor-suppressor genes. Methylation regions rich in CpG promoters prevent DNA transcription by changing the binding of histone complexes," explained P.K. Ha and colleagues,...
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