Recombinant Viruses
Recombinant hemagglutinin esterase-expressing hepatitis viruses are reduced in fitness
Published in Gene Therapy Weekly, March 16th, 2006
"Group 2 coronaviruses encode an accessory envelope glycoprotein species, the HE, which possesses sialate-O-acetylesterase activity and which, presumably, promotes virus spread and entry in vivo by facilitating reversible virion attachment to O-acetyllated sialic acids. While HE may provide a strong selective advantage during natural infection, many laboratory strains of mouse hepatitis virus (MRV) fail to produce the protein."
"Apparently," wrote A. Lissenberg and...
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Source: Gene Therapy Weekly (2006-03-16)
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