Apoptosis
Cathepsin D and H2 O2 stimulate apoptotic degradation of thioredoxin-1
Published in Gene Therapy Weekly, March 16th, 2006
"CatD is a lysosomal aspartic proteinase and plays an important role in the degradation of proteins and in apoptotic processes induced by oxidative stress, cytokines, and aging. All of these stimuli are potent inducers of endothelial cell apoptosis."
"Therefore," wrote J. Haendeler and colleagues, University of Frankfurt, "we investigated the role of CatD in endothelial cell apoptosis and determined the underlying mechanisms."
"Incubation with 100-500 mcM H2 O2 for 12 h induced...
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Source: Gene Therapy Weekly (2006-03-16)
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