Published in Gene Therapy Weekly, March 23rd, 2006
"Retrovirus assembly proceeds via multimerization of the major structural protein, Gag, into a tightly packed, spherical particle that buds from the membrane of the host cell.
"The lateral packing arrangement of the human immunodeficiency virus type 1 (HIV-1) Gag CA (capsid) domain in the immature virus has been described," scientists writing in the Journal of Molecular Biology report.
According to the authors, "Here we have used cryo-electron microscopy (cryo-EM) and image processing to determine the lateral and radial arrangement of Gag in in vivo and in...
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Source: Gene Therapy Weekly (2006-03-23)
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