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Renal Therapy

Fibrin microbeads provide a 3D platform for kidney gene and cell therapy

Published in Gene Therapy Weekly, March 23rd, 2006

According to a study from Israel, fibrin microbeads provide a three-dimensional (3D) platform for kidney gene and cell therapy.

"Cell and gene therapy may alter the outcome of renal diseases, such as hereditary nephropathies, acute and chronic glomerulonephritis and allograft nephropathy. However, owing to blockade of many viral and cellular vehicles by the complex glomerular architecture, the exact nature of gene and cell delivery into specific renal compartments remains currently unknown," wrote N. Shimony and colleagues, Hebrew University of Jerusalem.

"To study the interaction of viral vectors with a variety of renal cells and mesenchymal stem...

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