Pharmaceutical Research
Recombinant antithrombin inhibits thrombin formation and interleukin release in endotoxemia
Published in Gene Therapy Weekly, March 23rd, 2006
"We hypothesized that infusion of recombinant human antithrombin without concomitant heparin would have dose-dependent anticoagulant properties and potentially decrease endotoxin (lipopolysaccharide [LPS])-induced cytokine production," wrote J.M. Leitner and colleagues, Medical University of Vienna.
They explained, "This was a randomized, double-blind, placebo-controlled study in parallel groups enrolling 30 healthy male volunteers. The active treatment groups received infusions of recombinant human...
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Source: Gene Therapy Weekly (2006-03-23)
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