Physiology
Paracellular transport in Calu-3 cell layers is enhanced by Carbopol
Published in Gene Therapy Weekly, March 23rd, 2006
"The interaction of Carbopol polymers with mucus producing Calu-3 human bronchial epithelial cells was evaluated to test for potential paracellular transport enhancement," wrote L.L. Li and colleagues, Bristol Myers Squibb Co.
"Using desmopressin (1-deamino-8-arginine-vasopressin, DDAVP) as the model peptide, apical treatment with Carbopol polymer gel formulations resulted in molecular size-dependent permeability enhancement with a concomitant drop in the transepithelial electrical resistance (TEER)," the researchers reported.
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Source: Gene Therapy Weekly (2006-03-23)
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