Tumor Biology
EWS-Fli1 may function in evasion of senescence in Ewing family tumors
Published in Gene Therapy Weekly, March 23rd, 2006
"The chromosomal translocation t(11;22) yields the EWS-Fli1 fusion gene and is associated with oncogenesis of Ewing family tumors (EFT)," wrote T. Matsunobu and colleagues, Kyushu University.
"In this study, using the RNA interference method, we show that EWS-Fli1-targeting small interfering RNAs (siRNA) depleted EAVS-Fli1 protein and caused growth inhibition in EFT cells with the accumulation of p27 protein and the down-regulation of Skp2 protein in dose-dependent, time-dependent, and sequence-specific manners," the researchers from Japan...
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Source: Gene Therapy Weekly (2006-03-23)
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