Apoptosis

T cell infiltration is associated with apoptosis and rejection of tumor cells

Published in Gene Therapy Weekly, March 30th, 2006

According to research from the United States, infiltration of tumor-reactive transforming growth factor (TGF)-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells.

"TGF-beta is a potent immunosuppressant. High levels of TGF-beta produced by cancer cells have a negative inhibition effect on surrounding host immune cells and leads to evasion of the host immune surveillance and tumor progression.

"In the present study," wrote Q. Zhang and colleagues, Northwestern University, "we report a distinct ability of tumor reactive, TGF-beta-insensitive CD8+ T cells to infiltrate into established...

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Source: Gene Therapy Weekly (2006-03-30)

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