Enzymology

Evolutionary paths intelligently designed

Published in Gene Therapy Weekly, March 30th, 2006

Evolutionary paths to new therapeutic drugs, as well as a wide assortment of other enzyme products, have been created through, of all things, intelligent design.

A team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley have developed a technique in which the evolution of an important class of proteins is steered towards a desired outcome.

The Grand fir, largest of all the fir trees, produces the ultimate in "promiscuous enzymes," a sesquiterpene synthase capable of producing as many as 52 different enzyme products.

"We've taken enzymes that are promiscuous,...

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Source: Gene Therapy Weekly (2006-03-30)

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