Published in Gene Therapy Weekly, March 30th, 2006
"We and others have recently reported highly efficient liver gene transfer with AAV-8 pseudotypes, i.e., AAV-2 genomes packaged into AAV-8 capsids. Here we studied whether liver transduction could be further enhanced by using viral DNA packaging sequences (inverted terminal repeats [ITRs]) derived from AAV genotypes other than 2," wrote D. Grimm and colleagues, Stanford University. "To this end, we generated two sets of vector constructs carrying expression cassettes embedding a gfp gene or...
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