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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . April 6th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cancer Gene Therapy - BRCA1 and BRCA2 are molecular targets in breast and prostate cancer cells

Cancer Gene Therapy - Gastric cancer treatment aided by suicide gene therapy combined with hyperthermia

Cancer Gene Therapy - Triple anti-tumor gene transfer inhibits growth in glioblastoma cells

DNA Research - Modified oligonucleotides produce efficient and persistent gene silencing

RNA Research - Alu-linked hairpins efficiently mediate RNA interference

Allergy & Immunology - Modified Langerhans-type dendritic cells express full-length stimulatory antigen

Allergy & Immunology - Phospholipase is critical in macrophage engulfment

Allergy & Immunology - T cell activation is enhanced by mast cells

Alzheimer Disease - New findings in the area of Alzheimer disease detailed

Apoptosis - Modified endothelial cells initiate vascular endothelial growth factor-driven apoptosis

Bone Marrow - Hepatocyte-bone marrow cell fusion is driven by immune-mediated hepatitis

Breast Cancer - Breast cancer gene profiling is facilitated by Raf-1 protein kinase inhibition

Breast Cancer - Breast cancer treated with low doses of alpha particle irradiation

Breast Cancer - Herceptin sensitizes ErbB2-overexpressing cells to apoptosis

Cancer Gene Therapy - Combination gene therapy is effective for pancreatic adenocarcinoma

Cancer Gene Therapy - Findings in cancer gene therapy provide new insights

Cancer Gene Therapy - Methyltransferase depletion therapy mediates growth arrest and apoptosis

Cancer Gene Therapy - RNA interference inhibits the proliferation of pediatric hepatic tumors

Cancer Gene Therapy - Tumor cells can be sensitized to chemotherapeutic agents or TRAIL

Cancer Therapy - Cordycepin antitumor effect involves adenosine receptor stimulation

Cancer Therapy - Disease-free survival following breast cancer remission is improved by new treatment regimen

Cancer Vaccines - Recent findings in cancer vaccines provide new insights

Cancer Vaccines - Researchers detail new studies and findings in the area of cancer vaccines

Cell Biology - Cell aging is associated with downregulation of protein kinase CKII

Cell Biology - Nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands

Chronic Myelogenous Leukemia - Human leukemic cells killed by nuclear entrapment of BCR-ABL

DNA Research - Damaged DNA binding protein 1 contributes to genome stability in somatic cells

DNA Research - Protein-activation complex interaction underlies lipoprotein regulation

DNA Research - Sangamo BioScience, ZFP Therapeutics sign agreement to develop HIV program

Dermatology - Skin angiogenesis is modulated by placenta growth factor

Diabetes Complications - Activated p53 alters angiogenesis in diabetes

Drug Development - Lorus announces publication of studies related to anticancer therapies

Drug Resistance - New findings in drug resistance described

Finance - Targeted Genetics reports $3.5 million net loss in preliminary Q4 2005 financial results

Gene Research - Liver-specific lentiviral vector successfully treats UGT1A1 deficiency

Gene Research - Polymer-coated chick embryo lethal orphan virus can target mammalian cells

Head & Neck Cancer - U.S. FDA approves ERBITUX (Cetuximab) for treatment of head and neck cancer

Hemophilia - Ancient DNA helps researchers unearth potential hemophilia therapy

Hepatitis B Virus - Chronic hepatitis B virus replication utilizes covalently closed circular DNA

Hepatitis B Virus - HBV replication is blocked by asialoglycoprotein receptor antisense oligonucleotides

Hepatitis B Virus - HBV surface antigen used to generate high-affinity chimeric antibody

Hepatitis C Virus - Hepatitis C virus envelope functionally analyzed by cell-cell fusion assay

Hepatitis C Virus - Novel HCV vector overcomes anti-Ad5 immunity and induces immune responses

Hepatitis C Virus - Optimal hepatitis C virus replication requires helicase surface residues

Hepatitis Delta Virus - ADAR 1 enhances hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells

Hepatocellular Carcinoma - Up-regulation occurs in hepatocellular carcinomas of the HBx gene

Immunotherapy - GM-CSF genetic adjuvant promotes prophylactic DNA vaccination against pseudorabies

Immunotherapy - Monoclonal antibodies generated to native mouse angiotensin-converting enzyme

Myocardial Ischemia - Myocardial ischemia improved after treatment with proangiogenic gene therapy

Ophthalmology - Eyes with retinal ischemia improve after receiving XIAP gene therapy

Parkinson Disease - Parkinson disease behavioral recovery induced by stem cell-derived neurons

Patents - DiagnoCure wins U.S. patent for PCA3

Physiology - Receptor overexpression exaggerates locomotor and hypothermic response

Prostate Cancer - Prostate cancer apoptosis and growth inhibition induced by targeting c-myc gene

Prostate Cancer - Prostate cancer tumorigenic properties are suppressed by chromosome 18

Prostate Cancer - Prostate tumor development inhibited in a transgenic adenocarcinoma model

Proteomics - Protein kinase CK2 subunits are positive regulators of AKT kinase

Reconstructive Surgery - Findings in reconstructive surgery provide new insights

T Cells - T cell activation requires HuR nuclear export and cytokine mRNA stabilization

Tissue Engineering - Enzo receives approval to begin HIV clinical trial

Tumor Suppression - Tumor rejection by T cells involves NK-cell activation

Vaccine Delivery - DNA vaccine is targeted to skin with the use of electroporation

Vector Development - Recombinant vectors enable the transduction of pancreatic and colon carcinoma

Virology - Adenovirus vectors sustain inducible transgene expression in brain

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