Diabetes Complications
Activated p53 alters angiogenesis in diabetes
Published in Gene Therapy Weekly, April 6th, 2006
"Adverse metabolic factors, including oxidized small and dense low density lipoprotein (ox-dmLDL) can contribute to the reduced number and the impaired functions of circulating endothelial progenitors (EPC) in diabetic patients. To elucidate the molecular mechanisms involved, EPC from normal donors were cultured in the presence of alpha-dmLDL," scientists in Italy report.
"Under these experimental conditions EPC undergo senescent-like growth arrest. This effect is associated with Akt activation, p21 expression, p53 accumulation, and retinoblastoma protein dephosphorylation and with a reduced protective...
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Source: Gene Therapy Weekly (2006-04-06)
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