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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . April 13th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Liposome Delivery - Cationic liposome decoy complex suppresses tumor necrosis factor alpha

Neuroscience - Basic FGF expression in astrocytes affects dopamine neuron synaptic function and development

Ovarian Cancer - Effective ovarian cancer treatment strategies target Raf-1 mRNA

Prostate Cancer - Prostate cancers are effectively treated using oncolytic herpes simplex virus

RNA Interference - RNA interference allows transgenic screening

Allergy & Immunology - Autoantibodies to diacyl-phosphatidylethanolamine recognize cytoplasmic domains

Allergy & Immunology - T cell activation is increased in the absence of the autoimmune regulator

Antisense Technology - Antisense oligonucleotide library validates Eg5 as a drug development target

Apoptosis - An adenovirus mutant induces apoptosis and cell-cycle arrest in tumor cells

Apoptosis - Schisandrin B enhanced doxorubicin-induced apoptosis of cancer cells

Arthritis - Inflammatory bone destruction requires p38 MAPK activation

Breast Cancer - Breast cancer therapy utilizes retrovirus-mediated tk gene

Breast Cancer - Possible breast cancer therapy believed to be inhibition of Notch signaling

Business & Finance - Enzo Biochem reports second quarter results, HIV-1 Stealth Vector trial initiated

COX-2 - Cyclooxygenase-2 pre-mRNA targeted using antisense morpholino oligonucleotides

Cancer Gene Therapy - Bladder cancer growth is inhibited by an adenovirus expressing dual therapeutic genes

Cancer Gene Therapy - Cervical cancer cell death can be induced by E6 siRNA

Cancer Gene Therapy - Enhanced bladder cancer gene therapy involves restoration of viral receptor expression

Cancer Gene Therapy - New research in the area of cancer gene therapy detailed

Cancer Gene Therapy - Ovarian cancer metastasis is inhibited by adeno-associated virus-mediated gene transfer

Cancer Gene Therapy - Prostate cancer radiation therapy is aided by the use of gene therapy

Cancer Gene Therapy - Recent findings in cancer gene therapy described

Cancer Gene Therapy - Recent findings in cancer gene therapy provide new insights

Cancer Gene Therapy - Small interfering RNA-mediated depletion of CD44 v5 reduced tumor cell invasion

Cancer Gene Therapy - Tumor angiogenesis is suppressed by oncolytic replication-competent adenovirus

Cancer Therapy - Chemotherapy can be enhanced by molecular targeting of BCL2 and BCLXL proteins

Cancer Therapy - Prostate cancer cell superoxide production and apoptosis is enhanced by p53

Cancer Therapy - Recent findings in cancer therapy described

Cancer Therapy - Targeted tumor therapy is achieved using an antisense compound

Cardiology - Estrogen receptor alpha mediates potassium channel stimulation

Cardiology - GDF15/MIC-1 functions as a protective and antihypertrophic factor

Cardiology - Progressive myocardial ischemia stalls upon angiogenic induction by VEGF-C

Cell Differentiation - Skeletal muscle satellite cell differentiation requires lamin A/C and emerin

Chemotherapy - Inex licenses three targeted chemotherapy products to Hana Biosciences

Cholangiocarcinoma - Cholangiocarcinoma is treatable with combination virus-radiation therapy

Colon Cancer - Colon cancer targeting of parvoviruses is achieved by insertion in P4 promoter

Colorectal Cancer - Chemotherapy-induced colorectal cancer cell death inhibited by c-FLIP

DNA Research - Pausing during reverse transcription increases the rate of retroviral recombination

DNA Research - Smad3 regulates telomerase reverse transcriptase via growth factor beta

DNA Research - Two-step red-mediated recombination allows DNA manipulation in Escherichia coli

DNA Vaccine - DNA vaccine encoding Der p2 allergen down-regulates STAT6 expression

Developmental Biology - Gene expression of Cox5a, 5b, or 6b1 functions in preimplantation mouse embryos

Developmental Biology - Xenopus hypaxial myogenesis involves lbx1

Diet & Nutrition - Ghrelin neutralization ameliorates obesity in diet-induced obese mice

Drug Delivery - Cationic liposomes are promising in drug and gene delivery

Drug Delivery - Endosomes and lysosomes are the receptors for peptide localization

Drug Development - ALS Association funds study in monkeys of drug with potential to treat Lou Gehrig disease

Drug Development - Corroles are specifically delivered to tumor cells via noncovalent conjugates

Drug Development - Intravenous delivery of plasmid DNA generates antibody

Embryogenesis - Foxd3 mediates zebrafish myf5 expression during early somitogenesis

Embryogenesis - Nodal gene expression and signaling is cooperatively and autonomously regulated in Xenopus

Endocrinology - Growth hormone determines sexual dimorphism of hepatic cytochrome expression

Endometrial Cancer - Endometrial carcinoma chemoresistance involves placental leucine aminopeptidase

Endometrial Cancer - Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis

Gastric Cancer - Disseminated peritoneal scirrhous gastric cancer is responsive to gene-drug therapy

Gene Research - Cancer pathogenesis involves small noncoding microRNA

Gene Therapy - Cationic gene delivery polymer has been synthesized and characterized

Gene Therapy - Uronic acid functionalized copolymers can be synthetic gene carriers

Gene Therapy - Viral vectors activate endothelial cell signal transduction

Gene Transfer - LYVE-1 cDNA delivery creates blocking antibodies

Genetic Research - Compendia Bioscience obtains exclusive rights to commercialize Oncomine

Genetics & Genomics - Mycobacterial vaccination and infection induces transcriptional responses

Genetics & Genomics - Study results on ChondroGene's blood-based molecular diagnostics tests published in paper

Hematology - Neutrophil chemotaxis requires Hem-1 complexes

Hepatocellular Carcinoma - HCC tumorigenicity is reduced by knock-down of hepatitis B virus X protein

Herpes Simplex Virus - Treatment of intravaginal HSV-2 infection is aided by mucosal innate activation

Human Papillomavirus - Human papillomavirus-associated oropharyngeal cancers with favorable prognosis identified

Human Papillomavirus - Human papillomaviruses are genotyped by bead-based multiplex method

Imaging - Positron emission tomography targets oncolytic virus in prostate cancer therapy

Immunotherapy - Heat labile Escherichia coli enterotoxin is potential adjuvant for transcutaneous cancer immunotherapy

Leukemia - Adult T cell leukemia treated by curcumin

Leukemia - Myeloid leukemia cell differentiation involves a novel signaling molecule

Leukemia - Pre-B lymphoblastic leukemia cell aberrant splicing is induced by BCR-ABL1

Liposome Delivery - Liposome-DNA complexes inhibit tumor angiogenesis and elicit antitumor activity

Lymphoma - Studies describe new findings in lymphoma research

Melanoma - Melanoma is regressed in a murine model by RLIP76 depletion

Melanoma - Melanosomal targeting sequences target epitope presentation and mobilization

Multiple Sclerosis - Oligodendrocyte glycoprotein antibodies are diagnostic of early inflammation in multiple sclerosis

Neuroscience - Extracellular matrix-degrading proteases affect spatial learning and synaptic plasticity

Neuroscience - Neuroticism mediates serotonin transporter gene association with lifetime major depression

Neuroscience - Neurotoxicity is attenuated by adenoviral gene transfer of superoxide dismutase

Parkinson Disease - Research add new data to Parkinson disease body of knowledge

Personnel - Michael Shoup named SurModic's VP of quality, regulatory and clinical affairs

Personnel - Vesta Therapeutics names four researchers to newly formed scientific advisory board

Physiology - Intermedin activates aortic L-Arg/nitric oxide synthase/nitric oxide pathway

Physiology - Novel targets identified in a phosphatidylinositol 3-kinase-independent pathway

Physiology - RNA interference-based screen identifies MAP4K4/NIK as a negative regulator

Prostate Cancer - Prostate cancer epithelial cell channels display differential roles

Proteomics - Macrophage cholesterol homeostasis and inflammation involves adipocyte enhancer-binding protein 1

Stem Cell Research - Genetically corrected Fanconi anemia bone marrow cells can repopulate

Stem Cell Research - Stem cell-derived dendritic cells induce immunity against metastatic melanoma

Vector Development - Findings in vector development provide new insights

Vector Development - Recent findings in vector development provide new insights

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