Arthritis
Inflammatory bone destruction requires p38 MAPK activation
Published in Gene Therapy Weekly, April 13th, 2006
J. Zwerina and colleagues, Medical University of Vienna, wrote that the study was done "to investigate whether activation of p38 MAPK is a crucial signaling factor in inflammatory bone destruction mediated by tumor necrosis factor (TNF).
"Mice overexpressing TNF were treated with 2 different inhibitors of p38 MAPK, and the effect of this treatment on joint inflammation and structural damage was assessed. Human TNF-transgenic mice received systemic treatment with 2 different p38 MAPK inhibitors (RO4399247 and AVE8677). Treatment was started at the time of...
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Source: Gene Therapy Weekly (2006-04-13)
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