Cardiology

GDF15/MIC-1 functions as a protective and antihypertrophic factor

Published in Gene Therapy Weekly, April 13th, 2006

According to research from the United States, GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

"Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth factor (TGF)-beta superfamily, as a novel antihypertrophic regulatory factor in the heart," wrote J. Xu and colleagues, University of Cincinnati.

"GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy," researchers in the United States report. "To...

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Source: Gene Therapy Weekly (2006-04-13)

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