Cardiology

Progressive myocardial ischemia stalls upon angiogenic induction by VEGF-C

Published in Gene Therapy Weekly, April 13th, 2006

Progressive myocardial ischemia stalls upon angiogenic induction by vascular endothelial growth factor (VEGF)-C.

According to researchers in Finland, "Besides being a known lymphangiogenic activator, VEGF-C may express angiogenic potential by proteolytic cleavage and activation of endothelial cells. We assessed myocardial collateral formation and functional changes after adenovirus-mediated VEGF-C gene transfer in an ischemic porcine model."

"Fifteen Landrace piglets underwent Ameroid-induced gradual occlusion of the left circumflex artery (LCx) and consequent progressive myocardial ischemia. Three weeks after Ameroid placement, the animals underwent...

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Source: Gene Therapy Weekly (2006-04-13)

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