Published in Gene Therapy Weekly, April 13th, 2006
"Genetic screening is the most powerful method through which to uncover gene function. It has been applied very successfully in lower organisms but seldom attempted in mammalian species because of their long generation time.
"In this study, we exploit RNAi for its potential use in genetic screening in mice," wrote S.H. Peng and colleagues, Baylor College of Medicine. "We show that RNAi-induced gene knockdown can be generated through introducing small hairpin RNA-expressing constructs into the mouse as transgenes via conventional pronuclear...
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