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Leukemia

Adult T cell leukemia treated by curcumin

Published in Gene Therapy Weekly, April 13th, 2006

Adult T-cell leukemia (ATL) could be treated by curcumin.

According to a study from Japan, "Activation of the activator protein 1 (AP-1) plays a critical role in oncogenesis by human T-cell leukemia virus type 1 (HTLV-1), the etiologic agent of ATL, and is required for maintenance of the malignant phenotype. Curcumin (diferuloylmethane), the major pigment of the spice turmeric, has anti-tumor activity; however, the effect of curcumin against ATL has not been elucidated."

"In this study, we examined the effects of curcumin on AP-1 activity in HTLV-1-infected T-cell lines," explained M. Tomita and colleagues, University of Ryukyus. "Curcumin suppressed...

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