Melanoma
Melanoma is regressed in a murine model by RLIP76 depletion
Published in Gene Therapy Weekly, April 13th, 2006
"RLIP76/RALBP1 is a stress-responsive membrane protein implicated in the regulation of multiple cellular signaling pathways. It represents the predominant glutathione-conjugate transporter in cells, and our previous studies have shown that its inhibition by antibodies or depletion by short interfering RNA (siRNA) causes apoptosis in a number of cancer cell types," wrote S.S. Singhal and colleagues, University of Texas, Arlington. "The present studies were done to explore the potential clinical applicability of our previous observations by comparing the relative...
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Source: Gene Therapy Weekly (2006-04-13)
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