Cytotoxicity
Differential cytotoxicity expression is influenced by D-ring hydrogen bond donor
Published in Gene Therapy Weekly, April 20th, 2006
"The synthesis and biological evaluation of several enantio-enriched schweinfurthin B analogs were undertaken to develop structure-activity relationships and guide design of probes for their putative molecular target. The desired stilbenes contain a common left-half hexahydroxanthene ring system and an aromatic right-half with varied substituents," wrote J.D. Neighbors and colleagues, University of Iowa. "The synthesis involves penultimate Horner-Wadsworth-Emmons coupling of one of several right-half phosphonates with the aldehyde...
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Source: Gene Therapy Weekly (2006-04-20)
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