Keratitis
Herpetic stromal keratitis is suppressed by immunomodulation
Published in Gene Therapy Weekly, April 20th, 2006
"We investigated whether the course of HSK in BALB/c mice could be altered by topical gene-gun-mediated administration of interleukin (IL)-4 or IL-10 plasmid DNA," wrote D. Bauer and colleagues of St. Franziskus Hospital in Munster.
"Corneas of BALB/c mice were transfected with plasmids expressing beta-galactosidase (beta-gal), IL-4, IL-10, granulocytemacrophage colony-stimulating factor (GM-CSF), and pCR3.1 (control) 2 days before herpes simplex virus-1 (HSV-1; KOS) infection,"...
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Source: Gene Therapy Weekly (2006-04-20)
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