Retinoic Receptors
Retinoid X receptor ligand binding dynamics clarified
Published in Gene Therapy Weekly, April 20th, 2006
"RXRs are nuclear receptors that can activate transcription as homodimers or as obligate heterodimeric partners of other nuclear receptors. While the crystal structures of the RXR ligand-binding domains (LBD) have been previously determined, the dynamics of activation is less well characterized at an atomic level.
"To probe the effect of ligand binding on RXR LBD dynamics, we initiated nuclear magnetic resonance studies of recombinant human RXR alpha LBD (T223 T462) with and without bound 9-cis-retinoic acid (9cRA)," wrote J.Y. Lu...
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Source: Gene Therapy Weekly (2006-04-20)
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