Tumorigenesis
How to decrease p27(Kip1) levels during tumor development discussed
Published in Gene Therapy Weekly, April 20th, 2006
According to recent research from the United States, "P27(Kip1), a cyclin-cdk inhibitor, is a tumor suppressor. An overwhelming amount of data correlate p27 abundance to tumor prognosis in humans."
"Mouse models have supported the importance of decreasing p27 to tumor incidence. Inactivation of most tumor suppressors occurs at the level of gene mutation or silencing, but p27 is regulated posttranscriptionally, and how its level is reduced in cancer is largely unknown," explained A. Koff and colleagues, Memorial Sloan-Kettering Cancer Center.
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Source: Gene Therapy Weekly (2006-04-20)
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