Apoptosis
Co-expression of metallothionein and p53 implicated in tumor cell apoptosis
Published in Gene Therapy Weekly, April 20th, 2006
"Previous reports have shown that MT may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells," investigators in Canada reported.
"The results demonstrate an interaction between MT and p53 can occur in vitro. The complex between MT and p53 was observed in breast cancer epithelial cells with both wild and inactive type of p53. Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT," explained E.A. Ostrakhovitch and colleagues, University of Western...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2006-04-20)
More Articles from Gene Therapy Weekly
- Cancer Gene Therapy
Isoform-specific silencing defines Livin beta as key mediator of apoptosis inhibition - Gene Silencing
Imprinting control region affects the expression of Gnas cluster transcripts - Genetics & Genomics
MUC5AC gene expression in human lung epithelial cells is medicated by dexamethasone - Vector Development
Human peritoneal mesothelial cell growth factor expression is inhibited by shRNA - Adverse Drug Reaction
Adverse effects are associated with bone morphogenetic protein-2 use - Allergy & Immunology
An immunoadjuvant chaperone induces signals upon dendritic cell interaction - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
