Antisense Technology
Retinal ganglion cell transfection is achieved by retrograde transfer of antisense oligonucleotides
Published in Gene Therapy Weekly, April 27th, 2006
"Intravitreal administration of specific ODNs effectively downregulates gene expression in the retina but does not modulate it exclusively in RGCs. Expression of kynurenine aminotransferase II (KAT II) in RGCs has been well described in the literature," wrote S. Thaler and colleagues, University of Tubingen. "We describe a new method for downregulating cellular KAT II expression via transfection of RGC by retrograde transfer of ODN."
The authors explained,...
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Source: Gene Therapy Weekly (2006-04-27)
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