Cornea Transplantation
Corneal allograft rejection differentially involves CD8+ and CD8- T lymphocytes
Published in Gene Therapy Weekly, April 27th, 2006
"We examined the role of perforin and FasL in corneal allograft rejection mediated by CD8+ and CD8- T cells. BALB/c corneas were transplanted orthotopically into vascularized, 'high-risk' graft beds in C57BL/6 mice, perforin knockout mice and FasL-defective gld/gld mice," wrote J.Y. Niederkorn and colleagues, University of Texas, Dallas.
They explained, "CD8+ and CD8- T cells were collected following graft rejection and adoptively transferred to SCID mice, which were then challenged with BALB/c corneal...
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Source: Gene Therapy Weekly (2006-04-27)
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