Liver Cancer
Hepatocellular carcinoma prodrug cell killing activity clarified
Published in Gene Therapy Weekly, April 27th, 2006
"Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex virus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory bystander effect; (b) short-lived expression of the protein," wrote L.M. Cao and colleagues, Jiangsu Institute of Parasitic Diseases.
They continued, "To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance...
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Source: Gene Therapy Weekly (2006-04-27)
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