Neurogenesis
Abnormal NSC REST/NRSF and Myc expression causes cerebellar tumors by blocking neurogenesis
Published in Gene Therapy Weekly, April 27th, 2006
According to a study from the United States, "Medulloblastoma, one of the most malignant brain tumors in children, is thought to arise from undifferentiated neural stem/progenitor cells (NSCs) present in the external granule layer of the cerebellum. However, the mechanism of tumorigenesis remains unknown for the majority of medulloblastomas."
"In this study, we found that many human medulloblastomas express significantly elevated levels of both nZyc oncogenes, regulators of neural progenitor proliferation, and REST/NRSF, a transcriptional...
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Source: Gene Therapy Weekly (2006-04-27)
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