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Stem Cell Research

Tissue fibroblasts are derived from hematopoietic stem cells

Published in Gene Therapy Weekly, April 27th, 2006

Tissue fibroblasts are derived from hematopoietic stem cells.

"Recent studies have reported that bone marrow cells can give rise to tissue fibroblasts. However, the bone marrow cell(s) that gives rise to fibroblasts has not yet been identified," scientists writing in the journal Experimental Hematology report.

According to A.C. Larue and colleagues at the Medical University of South Carolina, "In the present study, we tested the hypothesis that tissue fibroblasts are derived from hematopoietic stem cells (HSCs) in vivo.

"These studies were conducted using mice whose hematopoiesis had been reconstituted by transplantation of...

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