Proteomics

Recombinant keratinocyte growth factor stability is enhanced by mutagenesis

Published in Gene Therapy Weekly, May 4th, 2006

According to recent research from the United States, recombinant keratinocyte growth factor (KGF) stability is enhanced by mutagenesis.

"Native sequence KGF is fairly unstable, as manifested by the loss of the monomeric native protein accompanied by the accumulation of aggregated species during storage at moderate temperatures," wrote E. Hsu and colleagues, Amgen Inc.

They continued, "Several different types of analogs were generated and the storage stability of the protein assessed. In the first type of analog one or more of the five cysteinyl residues in KGF were replaced; in the second class the N-terminal residues that included the first...

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Source: Gene Therapy Weekly (2006-05-04)

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